
JIB-04
CAS No. 199596-05-9
JIB-04 ( JHDM Inhibitor VII | NSC 693627 )
Catalog No. M13115 CAS No. 199596-05-9
JIB-04 is a pan-selective Jumonji histone demethylase inhibitor.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 39 | In Stock |
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10MG | 61 | In Stock |
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25MG | 82 | In Stock |
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50MG | 149 | In Stock |
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100MG | 259 | In Stock |
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200MG | 426 | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameJIB-04
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NoteResearch use only, not for human use.
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Brief DescriptionJIB-04 is a pan-selective Jumonji histone demethylase inhibitor.
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DescriptionJIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively.
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In VitroJIB-04 is consistently selective for cancer vs. normal cells, demonstrated by the higher sensitivity of lung and prostate cancer lines (with IC50?as low as 10 nM) compared to HBECs and PrSCs/PrECs. JIB-04 inhibits cellular Jumonji demethylase activity, and Jumonji levels affect JIB-04 action in cells. JIB-04 significantly inhibits the proliferation of GB cell lines and stem-enriched cultures. JIB-04 exerts its maximal inhibitory activity against KDM5A, and modulates the expression of genes involved in the control of cancer cell growth and leads to hypermethylation of H3K4. Furthermore, JIB-04 (2500 nM) activates the autophagy and apoptotic pathways and inactivates PI3K. JIB-04 also cooperates with TMZ in killing GB cells.
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In VivoJIB-04 results in a significant reduction in cancer-induced death rates in mice, prolonging survival. JIB-04 (60, 40 and 20 mg/kg, i.p.) reaches bioactive concentration in the brain of the mice. The orthotopic GB xenograft model shows a trend toward longer survival in JIB-04-treated mice with an Hazard Ratio of 0.5.
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SynonymsJHDM Inhibitor VII | NSC 693627
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorJMJD2A| JMJD2B| JMJD2D| JMJD2E| JARID1A
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number199596-05-9
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Formula Weight308.76
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Molecular FormulaC17H13ClN4
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Purity>98% (HPLC)
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SolubilityDMSO: 25 mg/mL warmed (80.96 mM)
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SMILESClC1=CN=C(N/N=C(C2=CC=CC=C2)/C3=NC=CC=C3)C=C1
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Chemical Name(E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wang, L., et al. Nat Commun, 2013. 4: p. 2035.
molnova catalog



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